Kindling suppresses primed-burst-induced long-term potentiation in hippocampal CA1
Bibliographic record
Abstract
In a previous study, we showed that partial hippocampal kindling in rats, a model of temporal lobe epilepsy, reduced the efficacy of presynaptic GABA(B) receptors in the CA1 area of hippocampal slices. In this study, we show that long-term potentiation (LTP) induced by theta-frequency primed bursts was suppressed in kindled as compared to control rats, but not in the presence of the GABA(B) receptor antagonists CGP35348 or CGP55845A. This is original evidence that LTP is suppressed by pathophysiological downregulation of GABA(B) autoreceptors. Control of postsynaptic inhibition by presynaptic GABA(B) receptors may provide a compensatory mechanism for controlling paroxysmal activity, with a side effect of blocking synaptic plasticity.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".