NEUROLOGIC IMPAIRMENT DUE TO VITAMIN E AND COPPER DEFICIENCIES IN CELIAC DISEASE
Bibliographic record
Abstract
Celiac disease is an immune-mediated intolerance to gluten, which is found in grains such as wheat and barley. Its estimated prevalence is ∼1% and it remains underdiagnosed in many countries. It causes an enteropathy leading to macro- and/or micronutrient malabsorption, most commonly of iron, vitamin B12, vitamin D, and calcium. Deficiencies of only one or a few nutrients are the most common manifestation of non-diarrheal, “silent” celiac disease, which accounts for 50% of initial presentations.1 Immune- and nonimmune mechanisms provoke diverse neurologic complications in celiac disease including peripheral neuropathy and ataxia.2 ### Case report. We investigated a 58-year-old French-Canadian man with 1 year of progressive leg stiffness and gait unsteadiness. He had mild, longstanding, biopsy-proven celiac disease presenting with dermatitis herpetiformis in 1980. He had received replacement therapy for iron-deficiency anemia and vitamin B12 deficiency during the last decade. There were no other symptoms of celiac disease and he did not adhere to a gluten-free diet. Two of five siblings have celiac disease without neurologic symptoms. CSF and urine examinations were normal. Blood studies revealed a mild microcytic anemia (131 g/L) with acanthocytes; mildly elevated transaminases; serum α-tocopherol (vitamin E) 2.22 × 10−3); serum ceruloplasmin 200 mg/L); …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".