Bibliographic record
Abstract
The objective of this section of the supplement is to discuss the multifactorial pathophysiology of the overactive bladder syndrome (OAB) and translate this knowledge into the clinical environment. There are two separate articles on the pathophysiology, with Dr. Christopher Chapple focusing on the role of central neurogenic pathways and Dr. Pradeep Tyagi discussing the local pathways (neurogenic, myogenic and urothelial). The new look into this area of human bladder innervations brings new ideas of how to approach voiding dysfunction and particularly OAB. This is important to finding other mechanisms of intervention in OAB; exploring central nervous system (CNS) and specific neurogenic pathways opens up new areas of research and intervention. In recognition of the multiple pathways of bladder dysfunction, medical science has identified many potential targets for pharmacologic intervention. The third article of this section by Dr. Karl-Erik Andersson is devoted to research into the future pharmacological compounds to be tested in OAB. In the subsequent sections of this publication, clinical aspects of therapeutic efficacy of current and emerging treatment agents will be discussed in even greater detail.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.003 |
| Scholarly communication | 0.002 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.010 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".