Structural studies on MsmE, a sugar binding lipoprotein, from<i>S. pneumoniae</i>
Bibliographic record
Abstract
Streptococcal organisms share a well-conserved, binding protein dependent, Multiple Sugar Metabolism (msm) system which is responsible for the transportation and metabolism of multiple sugars.This system is comprised of 8 proteins including 2 membrane proteins (MsmF and MsmG), an ATP-binding protein (MsmK) and the 45KDa sugar-binding lipoprotein MsmE [1].Both native and selenomethionine derivatised MsmE were crystallised in space group P6 1 22.Selenomethionine derivative crystals showed diffraction to 2.5Å and 3-wavelength MAD data were collected at SRS, Daresbury.Selenium sites (19/22) were found using SnB [2] with peak data and site refinement and phasing using Sharp/AutoSharp [3] using MAD data along with a 3Å native dataset.The initial model shows a two domain periplasmic binding protein-like fold and model-building and refinement is continuing.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".