A Case of Acute Heart Failure With Intravenous Acetazolamide Administration for Evaluation of Cerebrovascular Reactivity
Bibliographic record
Abstract
A man in his seventies presented with a history of cerebral infarction with occlusion of the left middle cerebral artery, diabetes mellitus, renal dysfunction, as well as prior myocardial infarction and arteriosclerosis obliterans. About 45 min after intravenous administration of 1,000 mg of acetazolamide for acetazolamide-augmented cerebrovascular single-photon emission computed tomography, he experienced dyspnea and tightness in his chest which worsened. Hypertension, regular tachycardia, and wheezing and rales were noted. Symptoms and vital signs did not improve despite many life-saving treatments. In patients with severe coronary artery disease with low ischemic threshold, as in the present case, acetazolamide might reduce peripheral vascular resistance, increase the cardiac output ratio, increase myocardial oxygen consumption by increasing cardiac output, and induce myocardial ischemia with elevation of double product. Although the frequency of acute heart failure due to myocardial ischemia after an acetazolamide challenge may be low, its occurrence in patients with severe arteriosclerotic disease should be routinely considered. doi: http://dx.doi.org/10.4021/jmc1315w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.004 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".