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Record W2039738742 · doi:10.3109/10408444.2011.554793

A review of epidemiologic studies of triazine herbicides and cancer

2011· review· en· W2039738742 on OpenAlexaff
Nalini Sathiakumar, Paul A. MacLennan, Jack S. Mandel, Elizabeth Delzell

Bibliographic record

VenueCritical Reviews in Toxicology · 2011
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRetinoids in leukemia and cellular processes
Canadian institutionsPublic Health OntarioUniversity of Toronto
Fundersnot available
KeywordsCancerMedicineLeukemiaLymphomaEpidemiologyOncologyPathologyInternal medicineSarcomaProstateCancer research

Abstract

fetched live from OpenAlex

This is an update of a previous review of epidemiological evidence pertaining to the human carcinogenic potential of triazine herbicides. In 36 studies evaluated, atrazine was the most common triazine investigated. In general the studies were limited by lack of in-depth exposure measurements and by small numbers of subjects with potential high exposure and/or with many years of follow-up since first exposure. Non-Hodgkin lymphoma, prostate cancer, and breast cancer were most frequently investigated. Only one to three analytical or ecological studies investigated Hodgkin lymphoma, leukemia, multiple myeloma, soft tissue sarcoma, hairy-cell leukemia, melanoma, and cancers of the ovary, testes, colon, stomach, lung, brain, bladder, buccal cavity, and pharynx. Results of these studies were typically imprecise and did not form an adequate basis for determining if triazine exposure causes any form of cancer. Collectively, the available epidemiology studies do not provide consistent, scientifically convincing evidence of a causal relationship between exposure to atrazine or triazine herbicides and cancer in humans. Based upon the assessment studies, there is no scientific basis for inferring the existence of a causal relationship between triazine exposure and the occurrence of cancer in humans.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0050.008
Science and technology studies0.0000.000
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.208
GPT teacher head0.489
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations141
Published2011
Admission routes1
Has abstractyes

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