Exaggerated Natriuresis in the Course of Poststreptococcal Glomerulonephritis
Bibliographic record
Abstract
The response to rapid infusion of 2.5% saline solution was examined in 21 patients 1–15 years after an episode of acute poststreptococcal glomerulonephritis. 12 were normotensive and 9 hypertensive; 11 had minimal proteinuria; renal biopsies showed varying degrees of glomerular sclerosis in 9 and were normal in the remainder; filtration rates ranged from 151 to 26 ml/min. Exaggerated natriuresis during the saline load occurred in 19 of the 21. The occurrence or magnitude of natriuresis was not dependent on the level of filtration rate or the presence of hypertension. The renal mechanism, which could not be attributed to increase in filtration rate, decrease in peritubular oncotic pressure, or increase in intrarenal pressure, is unexplained. It is suggested that this remarkably altered reactivity to saline loading reflects the presence of diseased nephrons and constitutes further evidence that irreversible renal damage occurs commonly following acute poststreptococcal glomerulonephritis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".