Extent of Agreement in Gentamicin Concentration Between Serum That Is Drawn Peripherally and From Central Venous Catheters
Bibliographic record
Abstract
OBJECTIVE: At our institution, patients who receive once-daily dosing of gentamicin have serum concentrations determined 3 and 6 hours after dose administration. Patients with single-lumen central venous catheters have the 3-hour samples drawn peripherally. The objective of this study was to evaluate the extent of agreement between peripheral and central venous catheter serum gentamicin concentrations drawn 3 hours after dose administration. METHODS: In this prospective, observational study, patients provided both a peripheral and a central blood sample for determination of serum gentamicin concentration. The order of sampling (central venous catheter versus peripheral first) was randomized. Agreement was assessed by determination of the intraclass correlation coefficient and Bland-Altman analysis. The clinically acceptable targets for the lower limit of the intraclass correlation coefficient and Bland-Altman limits of agreement were defined a priori as >0.80 and +/-6%, respectively. Differences between the theoretical dose adjustments using the central venous catheter versus the peripheral sample result were described. RESULTS: Forty-five pairs of samples were collected: 42 from single-lumen implantable central venous catheters (ports) and 3 from peripherally inserted central venous catheters. The intraclass correlation coefficient was 0.91. However, the Bland-Altman analysis resulted in a mean percentage difference (central venous catheter versus peripheral) of -0.92% and limits of agreement of -27.9% to 26.0%. The gentamicin dose adjustment based on the central venous catheter sample result would have led to clinically significant dose adjustments in 19 (42%) cases, when compared with the peripheral sample result. CONCLUSIONS: These results indicate a lack of agreement between peripheral and single-lumen central venous catheter samples. In particular, ports are not appropriate sites for monitoring serum gentamicin concentrations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.027 | 0.076 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".