Macrophage activation syndrome (MAS) in juvenile systemic lupus erythematosus (JSLE): an underrecognized complication?
Bibliographic record
Abstract
To define the characteristics of MAS complicating JSLE. Patients with JSLE and MAS were collected from: 1) Gaslini Institute of Genoa, Italy; 2) PRINTO and PRCSG investigators; 3) literature. Control groups of JSLE without MAS included 33 patients with active lupus seen at Gaslini Institute (SLE-GI) and 387 patients from a multinational study of damage in JSLE (SLE-MS). Clinical and laboratory features of MAS with (BM+) or without (BM-) bone marrow demonstration of haemophagocytosis were contrasted each other and with those of lupus without MAS. 20 BM+ and 18 BM-patients with JSLE-associated MAS were identified. Comparison of percentage frequency of the main clinical and laboratory features of MAS in patient groups is shown in table 1 . Features of MAS in patients with or without BM haemophagocytosis were comparable, except for a greater frequency of leukopenia in BM+ patients. This suggests that this complication is more common than previously realized. All features but leukopenia and fever discriminated well between MAS and active lupus without MAS.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".