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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

2003· article· en· 934 citations· W2040671431 on OpenAlex· 10.1038/ng1219

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.016
GPT teacher head0.259
Teacher spread
0.243 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Genetics
Topic
Genetic Neurodegenerative Diseases
Field
Neuroscience
Canadian institutions
University of British Columbia
Funders
Keywords
HuntingtinBiologyTranscription factorHuntington's diseaseHuntingtin ProteinRepressorGeneticsGene silencingTranscription (linguistics)Cell biologyGeneMutantInternal medicineMedicine
Has abstract in OpenAlex
no