Biotin-Terminated Ruthenium Bipyridine Ring-Opening Metathesis Polymerization Copolymers: Synthesis and Self-Assembly with Streptavidin
Bibliographic record
Abstract
We present the synthesis of ring-opening metathesis polymerization block polymers containing a ruthenium bipyridine luminescent block and a hydrophobic block and end-terminated with a biologically active biotin molecule. These copolymers undergo self-assembly in water into star micelles containing a large number of luminescent Ru(II) centers, with the hydrophobic block in their core and the molecular recognition unit biotin at their periphery. Addition of the protein streptavidin results in the cross-linking of these polymer nanospheres, through biotin−steptavidin binding, into extended networks. In addition to its usefulness as a method to organize polymeric nanostructures into biochemically addressable networks, this study has generated luminescent micellar aggregates capable of binding to biological compounds, and thus useful for the luminescence detection and signal amplification of biomolecules.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".