Exogenous Fibronectin Requirement for Adhesion by Neoplastic Human Cells
Bibliographic record
Abstract
We have studied the effect of serum, plasma and plasma fibronectin on the spreading behavior of several normal and neoplastic human cells using a quantitative spreading assay. Normal human cells are rich in surface fibronectin and are able to spread in the absence of serum or exogenous fibronectin. Virus-transformed cells and cells of neoplastic origin have reduced or no recognizable surface fibronectin and are dependent on serum or plasma for spreading. In agreement with previous studies on rodent cells, fibronectin appears to be the major factor responsible for this effect. Neoplastic cells can spread on fibronectin-coated substrata or can recruit fibronectin directly from the medium. The capacity of transformed cells to recruit fibronectin from the medium correlates with the presence of intercellular fibronectin as seen by the immunofluorescence technique on monolayer cultures. Our results are in keeping with the concept that neoplastic cells may be dependent on extracellular fibronectin for adherence in vivo and that this dependency may vary between different cell types.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".