Liposomes Tethered to Omega-Functional PEG Brushes and Induced Formation of PEG Brush Supported Planar Lipid Bilayers
Bibliographic record
Abstract
Self-assembly of planar supported lipid bilayers on top of hydrophilic polymer brushes is a desirable alternative to solid supported lipid bilayers and covalently tethered lipid bilayers for applications like sensing on transmembrane proteins which require a large aqueous volume between membrane and substrate. We present a simple dip-and-rinse method to produce poly(ethylene glycol) (PEG) brushes with sparse positively charged hydrophobic tethers, using poly(l-lysine)-graft-poly(ethylene glycol)-quaternary ammonium compound copolymers. The interaction of such polymer coatings with liposomes of different compositions and the conditions for formation of planar lipid bilayers of extraordinarily high fluidity on top of the >10 nm thick reservoir by liposome self-assembly and sequentially triggered rupture are investigated.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".