Bibliographic record
Abstract
Nucleoside transporters are a group of poorly understood membrane proteins involved in the movement of nucleoside and many nucleoside analogs across cell membranes. Nucleoside analog drugs are used routinely in various types of chemotherapy. These drugs have been widely used for many years with good results. However, variability in patient response and both de novo and acquired resistance continue to be major obstacles in effective chemotherapy. In combination with the development of new nucleoside analog drugs, a concerted effort is underway to improve our understanding of the genomics and proteomics of nucleoside transporters in order to identify the factors that influence individual patient responses. Here, we describe recent important contributions to our understanding of the genomics and proteomics of this group of proteins with reference to drug bioavailability. In addition, we discuss future approaches, which will provide further insights into nucleoside transporters structure and function. Keywords: ENT genes, Promoter Analyses, transcriptional regulators, amino-terminal motifs, nucleoside transport protein
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".