Effect of ETA receptor antagonist and aldosterone antagonist on blood pressure and vascular remodeling in aldosterone-infused rats
Bibliographic record
Abstract
Endothelin and aldosterone play an important role in vascular remodeling in hypertension. Our previous results demonstrate that endothelin-1 is involved in vascular remodeling in aldosterone and salt-induced hypertension. The aim of this study was to evaluate the effects of the ETa receptor antagonist BMS 182874 and of the aldosterone antagonist spironolactone on blood pressure and vascular remodeling in aldosterone-infused rats. Male Sprague-Dawley rats were infused with aldosterone (0.75μg/h) subcutaneously. BMS 182874 (40 mg/kg/d) and spironolactone (25mg/kg/d) were given with food for 6 weeks. Systolic BP was monitored by the tail-cuff method and effects on mesenteric resistance arteries were studied on a pressurized myograph. Aldosterone infusion increased BP (to 149 ± 5.8 vs 115 ± 1.2 mmHg in control, p<0.01) and media thickness of small arteries (to 17.7 ± 0.9 vs 13.6 ± 0.8 μm in control, p<0.05). BMS 182874 and spironolactone treatment decreased systolic BP (118 ± 5.1 and 120 ± 3.6 mmHg, respectively, p<0.01 vs untreated) and normalized media thickness of resistance arteries (14.2 ± 0.7 and 14.4 ± 0.6 μm, respectively, P<0.05 vs untreated) of aldosterone-infused rats. The elevation in BP and the vascular remodeling of small arteries in aldosterone-infused rats in the absence of salt loading may be mediated by ETa receptor. Blockade of the endothelin system may exert beneficial effects on vascular remodeling in aldosterone-induced hypertension.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".