Effects of Acute Transmural Pressure Elevation on Endothelium-Dependent Vasodilation in Isolated Rat Mesenteric Veins
Why this work is in the frame
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Bibliographic record
Abstract
<b><i>Background/Aims:</i></b> The vascular regulatory function of the endothelium can be impaired by increases in transmural pressure (TMP). We tested the hypothesis that increasing TMP impairs the endothelial dilator function of rat mesenteric small veins (MSVs). <b><i>Methods:</i></b> In PGF2α-preconstricted MSVs, bradykinin (BK), sodium nitroprusside (SNP) and <i>S</i>-Nitroso-<i>N</i>-acetylpenicillamine (SNAP) concentration-response curves were generated at intermediate (6 mm Hg) and high (12 mm Hg) pressures. BK-induced vasodilation was examined in the absence and presence of nitric oxide synthase inhibitor [N<sup>&#x03C9;</sup>-nitro-<smlcap>L</smlcap>-arginine (<smlcap>L</smlcap>-NNA), 100 µ<smlcap>M</smlcap>], cyclooxygenase inhibitor (indomethacin, 1 µ<smlcap>M</smlcap>), and large (BK<sub>Ca</sub>, paxilline, 500 n<smlcap>M</smlcap>) and small (SK<sub>Ca</sub>, apamin, 300 n<smlcap>M</smlcap>) conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel blockers. <b><i>Results:</i></b> BK, SNP and SNAP responses were not altered by TMP increases. BK-induced vasodilation was significantly reduced by <smlcap>L</smlcap>-NNA, indomethacin, apamin and paxilline at 6 mm Hg and <smlcap>L</smlcap>-NNA at 12 mm Hg, and was further reduced by coapplication of apamin and/or paxilline with <smlcap>L</smlcap>-NNA compared with responses obtained with either blocker. Endothelium removal completely abolished BK-induced vasodilation. <b><i>Conclusion:</i></b> Venous endothelial dilator function is not affected by TMP elevation. BK-induced vasodilation is completely dependent on the presence of functional endothelial cells and mediated in part by nitric oxide, BK<sub>Ca</sub> and SK<sub>Ca</sub> channels, while the participation of prostacyclin may be important at intermediate pressures.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it