Regenerative arrest of inflamed peripheral nerves: role of nitric oxide
Bibliographic record
Abstract
Inflammation can both support and hinder regeneration. In this work, we asked whether regeneration of peripheral nerve axons is facilitated or interrupted when it proceeds through a zone of local but nondirected inflammation. Regeneration was examined in new nerve bridges forming through conduits connecting transected rat sciatic nerves. The conduits, infused with lipopolysaccharide to generate a sterile and nondirected inflammatory response, had substantial rises in inducible nitric oxide (iNOS) mRNA synthesis. iNOS was expressed within macrophages just beyond the zone of axon regrowth. Under these conditions, there was complete interruption of regenerative bridge formation in all instances without axon regrowth across the transection. In a separate cohort, infusion of a broad-spectrum NOS inhibitor (Nomega-nitro-L-arginine-methyl ester) into the conduit salvaged bridge formation in a proportion (3/8) of rats. Our findings indicate that local inflammatory conditions inhibit regenerative events and that nitric oxide may contribute to these events.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".