Can we get away from serum total testosterone in the diagnosis of andropause?
Bibliographic record
Abstract
Because of its multifactorial origin, andropause is usually considered as a clinical entity whose diagnosis is difficult. Practitioners sometimes distrust the symptoms and the diagnostic tools. The clinical manifestations are however the reflection of a lack of anabolism commonly associated with a decreased production of testosterone which is translated in decreased serum values of total testosterone, bioavailable testosterone and calculated values of testosterone. Because of the similarity between the age of the control group and of andropausal men in this study, the Sex Hormone Binding Globulin dogma postulating a modest increase of the glycoprotein with age is evacuated from the argument and therefore it is proposed to rely on total testosterone as a first line assay to support the diagnosis of andropause; however the presence of confounding factors to the diagnosis sometimes require an easy access to calculated values of free or bioavailable testosterone.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.011 | 0.042 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.001 | 0.005 |
| Scholarly communication | 0.002 | 0.009 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.008 | 0.010 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".