Abstracts: 2nd International Conference on High Dose Chemotherapy: Innovation and Evolution
Bibliographic record
Abstract
The 2nd International Conference on High Dose Chemotherapy: Innovation and Evolution was held April 9-12, 2002, in Banff, Alberta, Canada. It was the follow-up conference to the successful EBMT International Conference on High Dose Chemotherapy in Breast and Ovarian Cancer which was held in Florence, Italy, in September 2000. In the last two years, the transplantation for solid tumors has been experiencing a major shift in thinking. Only randomized prospective Phase III studies representing level I evidence will be taken into consideration in the future. Data derived from such studies will change clinical practices. It is expected that survival benefit must be identified in a magnitude that is exceeding the usual. Statistical significance will not be sufficient and major clinical impact must be identified. Due to such a shift in thinking about high dose chemotherapy for solid tumors, our subtitle ″Innovation and Evolution" was chosen to identify the new developments of the transplantation concept. At our conference, three topics were covered by the distinct international faculty. The first session dealt with high dose chemotherapy and reports on phase III trials in metastatic breast cancer, high-risk early breast cancer, and ovarian cancer from North America, Europe, Australia, and Japan. The second session dealt with immunotherapy using the cellular product (allogeneic and autologous) or monoclonal antibodies. Finally, the third session focused on targeted therapeutics which have experienced a tremendous boom over the last three years. The identification and sequencing of the human genome with its logical consequence proteonomics has allowed researchers to identify molecular pathways that are instrumental in tumorgenesis. Whether or not we can use these targets for therapy and how to deal with the novel molecules in clinical studies was the topic concluding the scientific sessions. On the following pages, please find the abstracts of papers that were presented along with the abstracts that were accepted for the poster session. I trust that the goal to identify the status of high dose chemotherapy as well as its innovation and evolution was met. We will reconvene for the 3rd International Conference on High Dose Chemotherapy in Ankara, Turkey, in September 2004. Biol Blood Marrow Transplant 2002;8(6):336-47.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.005 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.105 | 0.048 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".