Deep vertical collagen fibrils play a significant role in mechanics of articular cartilage
Bibliographic record
Abstract
The primary orientation of collagen fibrils alters along the cartilage depth; being horizontal in the superficial zone, random in the transitional zone, and vertical in the deep zone. Commonly used confined and unconfined (when with no underlying bone) testing configurations cannot capture the mechanical role of deep vertical fibril network. To determine this role in cartilage mechanics, an axisymmetric nonlinear fibril-reinforced poroelastic model of tibial cartilage plateaus was developed accounting for depth-dependent properties and distinct fibril networks with physical material properties. Both creep and relaxation indentation models were analyzed which results were found equivalent in the transient period but diverged in post-transient periods. Vertical fibrils played a significant role at the transient period in dramatically increasing the stiffness of the tissue and in protecting the solid matrix against large distortions and strains at the subchondral junction. This role, however, disappeared both with time and at loading rates slower than those expected in physiological activities such as walking. The vertical fibrils demonstrated a chevron-type deformation pattern that was further accentuated with time in creep loading. Damages to deep vertical collagen fibril network or their firm anchorage to the bone, associated with bone bruises, for example, would weaken the transient stiffness and place the tissue at higher risk of failure particularly at the deep zone.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".