Low doses of ultraviolet radiation stimulate cell activity in collagen‐based scaffolds
Bibliographic record
Abstract
Cardiovascular diseases are increasingly becoming the main cause of death all over the world, leading to an increase in the economical and social burden. Vascular tissue engineering (VTE) is paving its routes toward challenging applications, focused mainly on substitutions of small-diameter blood vessels (<6 mm). Native collagen, a natural biological material which possesses extraordinary properties in terms of biocompatibility, has been extensively investigated as a scaffold for VTE. However, collagen is mainly extracted from collagen-rich native natural tissues by different harsh chemical and physical treatments, resulting in a solution susceptible to be processed for the fabrication of supports. These treatments imply the destruction of the native organization of the collagen microstructure, thus resulting in a collagen-based support less resistant in terms of mechanical properties than the native one. Therefore, different approaches have been investigated to increase these mechanical properties. Although UV irradiation present a strong potential for efficient crosslinking collagen macromolecules, the undesirable effects of UV on cell activity still remain the main challenge to be overpassed. The aim of this study was to investigate the potential of UV radiation and glycation for the crosslinking of collagen gels, with particular concern to the cells and capacity of the cells to remodel the collagen structure.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".