Phospholipid-mediated signaling in diseased myocardium
Bibliographic record
Abstract
Phospholipase (PL)A1 is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. Although PLA1 activities have been detected in many organisms and tissues, their functions have not been elucidated until recently. Currently, six extracellular and three intracellular PLA1 enzymes are known in mammals. The extracellular PLA1s consist of phosphatidylserine (PS)-specific PLA1 (PS-PLA1), membraneassociated phosphatidic acid (PA)-selective PLA1s (mPA-PLA1 and mPA-PLA1 ), hepatic lipase (HL), endothelial lipase (EL) and pancreatic lipas–elated protein (PLRP)-2, all of which belong to the lipase gene family. PS-PLA1, EL, mPA-PLA1 and mPA-PLA1 prefer phospholipid substrates, whereas HL and PLRP-2 show both PLA1 activity and lipase activity to hydrolyze triacylglycerol. EL has a role in high-density lipoprotein (HDL) metabolism by hydrolyzing phosphatidylcholine on HDL particles. PS-PLA1, mPA-PLA1 and mPA-PLA1 have distinct structural features in two surface loops (the lid and the 9 loop), which are implicated in substrate recognition. PS-PLA1, mPA-PLA1 and mPA-PLA1 specifically hydrolyze PS and PA, respectively, and produce their corresponding lysophospholipids (lysophosphatidylserine and lysophosphatidic acid), which have been defined as lipid mediators with multiple biological functions. Thus, these PLA1s may have a physiological role in the production of these lysophospholipid mediators. The intracellular PLA1s consist of PA-preferring PLA1, KIAA0725p and p125 in mammals, all of which are conserved in a wide range of organisms and have been implicated in vesicular transport.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".