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Drug dosing in children – special considerations

2006· article· en· W2044690478 on OpenAlexaff
Paul B. Pencharz

Bibliographic record

VenueHaemophilia · 2006
Typearticle
Languageen
FieldMedicine
TopicPharmaceutical studies and practices
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
Fundersnot available
KeywordsLean body massMedicineProtein metabolismMetabolismBody weightProtein turnoverEnergy metabolismPhysiologyDosingEndocrinologyInternal medicineProtein biosynthesisBiologyBiochemistry

Abstract

fetched live from OpenAlex

Summary. During growth the body composition, protein and energy metabolism of children changes. This paper aims to assess these changes as they relate to factors which might affect the metabolism of factor concentrates, through a review of body composition, protein and energy metabolism literature in childhood. Key findings were that protein metabolism is four times higher in neonates and twice as high in infants as compared with adults. In addition the interstitial fluid space in infants and younger children is approximately double that in adults. On the basis that protein metabolism relates most closely to lean body mass, which in turn relates to body weight one can conclude that factor concentrate doses should be based on body weight. We concluded that clearance of protein factor concentrates might be faster in infants and young children due to their higher protein turnover rate.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.096
Threshold uncertainty score0.906

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.326
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2006
Admission routes1
Has abstractyes

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