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Record W2045030683 · doi:10.1007/s00125-010-1747-3

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

2010· article· en· W2045030683 on OpenAlexaff
Jan A. Ehses, Daniel T. Meier, Stephan Wueest, Julia M. Rytka, Simone Boller, Peter Y. Wielinga, Anica Schraenen, Katleen Lemaire, Sarah Debray, Leentje Van Lommel, J. Andrew Pospisilik, Oliver Tschopp, Simon M. Schultze, Ursula Malipiero, Harald Esterbauer, Helga Ellingsgaard, Sabine Rütti, Frans Schuit, Thomas A. Lutz, Marianne Böni‐Schnetzler, Daniel Konrad, Marc Y. Donath

Bibliographic record

VenueDiabetologia · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDiabetes and associated disorders
Canadian institutionsChild and Family Research InstituteUniversity of British Columbia
FundersSystemsX.chEuropean Foundation for the Study of DiabetesUniversität ZürichAmgenKU LeuvenGebert Rüf StiftungSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEuropean Association for the Study of DiabetesNational Science Foundation
KeywordsInternal medicineEndocrinologyInsulin resistanceTLR2InflammationBiologyGlucose homeostasisImpaired glucose toleranceNEFAPancreatic isletsInsulinCarbohydrate metabolismAdipose tissueInsulin receptorReceptorInnate immune systemIsletMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.185
Teacher spread0.181 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations225
Published2010
Admission routes1
Has abstractno

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