Treating isolated systolic hypertension prevented major cardiovascular events across strata of risk in older patients
Bibliographic record
Abstract
(2001) Circulation 104, 1923; Ferrucci L, Furberg CD, Penninx BW, et al. . Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. . Oct 16; . : . –6 . [OpenUrl][1][Abstract/FREE Full Text][2] QUESTION: In older patients with isolated systolic hypertension (ISH), is blood pressure (BP) lowering treatment more effective than placebo for preventing major cardiovascular disease (CVD) events in those at high risk than in those at low risk? Randomised {allocation concealed*}†, blinded (outcome assessors),* placebo controlled trial with 4.5 years of follow up (subgroup analysis of the Systolic Hypertension in the Elderly Program [SHEP] trial). {5 clinical centres in the US}†. 4736 community dwelling patients who were ≥ 60 years of age and had ISH (systolic BP 160 to 219 mm Hg and diastolic BP < 90 mm Hg assessed and averaged over 2 visits), no atrial fibrillation, and no history of myocardial infarction (MI) or stroke in the previous 6 months. Patients taking antihypertensive medications were eligible if their … [1]: {openurl}?query=rft.jtitle%253DCirculation%26rft.stitle%253DCirculation%26rft.issn%253D0009-7322%26rft.aulast%253DFerrucci%26rft.auinit1%253DL.%26rft.volume%253D104%26rft.issue%253D16%26rft.spage%253D1923%26rft.epage%253D1926%26rft.atitle%253DTreatment%2Bof%2BIsolated%2BSystolic%2BHypertension%2BIs%2BMost%2BEffective%2Bin%2BOlder%2BPatients%2BWith%2BHigh-Risk%2BProfile%26rft_id%253Dinfo%253Adoi%252F10.1161%252Fhc4101.097520%26rft_id%253Dinfo%253Apmid%252F11602495%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=circulationaha&resid=104/16/1923&atom=%2Febmed%2F7%2F4%2F109.atom
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Commentary About the Canadian research system: no · About a Canadian topic: no | Not applicable | low |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Other design | low |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".