Malleability of human skeletal muscle sarcoplasmic reticulum to short-term training
Bibliographic record
Abstract
This study investigated the hypothesis that adaptations would occur in the sarcoplasmic reticulum in vastus lateralis soon after the onset of aerobic-based training consistent with reduced Ca²⁺-cycling potential. Tissue samples were extracted prior to (0 days) and following 3 and 6 days of cycling performed for 2 h at 60%-65% of peak aerobic power (VO₂(peak)) in untrained males (VO₂(peak) = 47 ± 2.3 mL·kg⁻¹·min⁻¹; mean ± SE, n = 6) and assessed for changes (nmol·mg protein⁻¹·min⁻¹) in maximal Ca²⁺-ATPase activity (V(max)), Ca²⁺-uptake, and Ca²⁺-release (phase 1 and phase 2) as well as the sarcoplasmic (endoplasmic) reticulum Ca²⁺-ATPase (SERCA) isoforms. Training resulted in reductions (p < 0.05) in SERCA1a at 6 days (-14%) but not at 3 days. For SERCA2a, reductions (p < 0.05) were also noted only at 6 days (-7%). For V(max), depressions (p < 0.05) were found at 6 days (172 ± 11) but not at 3 days (176 ± 13; p < 0.10) compared with 0 days (192 ± 11). These changes were accompanied by a lower (p < 0.05) Ca²⁺-uptake at both 3 days (-39%) and 6 days (-48%). A similar pattern was found for phase 1 Ca²⁺-release with reductions (p < 0.05) of 37% observed at 6 days and 23% (p = 0.21) at 3 days of training, respectively. In a related study using the same training protocol and participant characteristics, microphotometric determinations of V(max) indicated reductions (p < 0.05) in type I at 3 days (-27%) and at 6 days (-34%) and in type IIA fibres at 6 days (-17%). It is concluded that in response to aerobic-based training, sarcoplasmic reticulum Ca²⁺-cycling potential is reduced by adaptations that occur soon after training onset.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".