Electrolyte Transport Responses to Secretagogues in Neonatal versus Adult Rabbit Jejunum
Bibliographic record
Abstract
The ability of the neonatal and adult rabbit jejunum to respond to different exogenous stimuli of electrolyte transport was investigated in vitro. When mounted in Ussing chambers, jejunum from neonatal rabbits exhibited a higher basal short circuit current and lower potential difference compared to jejunum from adult rabbits. As a result, basal conductance was approximately 50% higher in the neonatal group. When the tissue was subjected to electrical field stimulation, neonatal jejunum was significantly less responsive to stimulation with respect to change in short circuit current, particularly at submaximal stimulus strength and stimulus duration. The neonatal jejunum was less responsive than adult jejunum to exogenous application of prostaglandin E2 and 5-hydroxytryptamine, and more responsive to histamine. There was no significant difference in the responses to carbachol, epinephrine, leukotriene D4 or platelet-activating factor. The neonatal rabbit jejunum exhibited a greater capacity to synthesize prostaglandin E2 and the peptidoleukotrienes, and had a higher tissue content of 5-hydroxytryptamine than the adult rabbit jejunum.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".