Synthesis and Molecular Recognition of Conjugated Polymer with DNA-Mimetic Properties
Bibliographic record
Abstract
The synthesis of a new DNA-mimetic π-conjugated poly( p -phenylenebutadiynylene) (polymer 9 ), which is functionalized with thymine nucleobases, as well as polyethylene glycol chains at every repeat unit is reported. This polymer was characterized by UV−vis, fluorescence, nuclear magnetic resonance, infrared, and Raman spectroscopy as well as gel permeation chromatography. These show its water-induced aggregation and a sharp transition from the aggregated phase to a more molecularly dissolved species when the temperature is increased. Molecular recognition properties of 9 with a number of guest molecules, including (i) 2,6-diacetamidopyrimidine and thymine derivatives in chloroform, (ii) adenosine and thymidine in water, and (iii) DNA d[A 20 ] and DNA d[T 20 ] in water, were investigated by UV−vis, fluorescence, thermal denaturation, circular dichroism (CD), nuclear magnetic resonance, and some control experiments. These results demonstrate that polymer 9 selectively binds complementary small molecules, both in organic solvents and in water, with concomitant enhancement in its fluorescence intensity and effectively discriminates between complementary and noncomplementary molecules. Importantly as well, this polymer forms a complex with complementary DNA, which shows enhanced fluorescence, a sharp thermal transition reminiscent of a natural DNA duplex, and a dramatic change in the secondary structure of the DNA guest. This is the first example of the hydrogen-bonding association of a conjugated polymer selectively to complementary DNA, with excellent discrimination between complementary and noncomplementary strands. Thus, the incorporation of nucleobases into conjugated polymers presents a useful tool to control chain−chain interactions and phototophysical properties through selective binding to DNA and its derivatives, to evolve sensor platforms for these biomolecules, and to possibly probe and modify the structure of the guest DNA.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".