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Record W2047736126 · doi:10.1126/science.291.5507.1363

Worth Its Weight in Gold

2001· article· en· W2047736126 on OpenAlexaff
Moı̈se Bendayan

Bibliographic record

VenueScience · 2001
Typearticle
Languageen
FieldMedicine
TopicMonoclonal and Polyclonal Antibodies Research
Canadian institutionsUniversité de Montréal
Fundersnot available
KeywordsImmunocytochemistryColloidal goldElectron microscopeAntigenBridging (networking)NanotechnologyColloidal particleBiologyComputational biologyBiophysicsChemistryColloidMaterials scienceComputer scienceImmunologyNanoparticleOpticsPhysics

Abstract

fetched live from OpenAlex

Immunocytochemistry, bridging morphology to biochemistry, has reached unsurpassed levels of sensitivity and resolution with the introduction of electron microscope markers using colloidal gold particles. The use of such markers has allowed for quantitative evaluations of antigens as well as multiple labelings of various antigens within the same cellular compartment. Other technological advances in tissue preparation techniques and molecular biology methods have significantly improved the versatility of immunocytochemistry. The advantages and some limitations of the new methods are discussed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.022
Threshold uncertainty score0.073

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.010
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0030.008
Scholarly communication0.0040.008
Open science0.0020.004
Research integrity0.0050.007
Insufficient payload (model declined to judge)0.0220.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.354
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations81
Published2001
Admission routes1
Has abstractyes

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