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New genetic loci link adipose and insulin biology to body fat distribution
Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau‐Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph Wu, Martin L. Buchkovich, Nancy L. Heard‐Costa, Tamara S. Roman, Alexander Drong, Ci Song, Stefan Gustafsson, Felix R. Day, Tõnu Esko, Tove Fall, Zoltán Kutalik, Jian’an Luan, Joshua C. Randall, André Scherag, Sailaja Vedantam, Andrew R. Wood, Rudolf S.N. Fehrmann, Juha Karjalainen, Bratati Kahali, Ching‐Ti Liu, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bragg‐Gresham, Steven Buyske, Ayşe Demirkan, Georg Ehret, Mary F. Feitosa, Anuj Goel, Anne Jackson, Toby Johnson, Marcus E. Kleber, Kati Kristiansson, Massimo Mangino, Irene Mateo Leach, Carolina Medina‐Gómez, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Alena Stančáková, Toshiko Tanaka, Alexander Teumer, Jana V. van Vliet‐Ostaptchouk, Loïc Yengo, Weihua Zhang, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Stefan Böhringer, Fabrice Bonnet, Yvonne Böttcher, Marcel Bruinenberg, Delia B. Carba, Ida Henriette Caspersen, Robert Clarke, E. Warwick Daw, Joris Deelen, Ewa Deelman, Graciela Delgado, Alex S. F. Doney, Niina Eklund, Michael R. Erdos, Karol Estrada, Elodie Eury, Nele Friedrich, Melissa E. Garcia, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Jagvir Grewal, Christopher J. Groves, Toomas Haller, Göran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Kauko Heikkilä, Karl‐Heinz Herzig, Quinta Helmer, Hans L. Hillege, Oddgeir L. Holmen, Steven C. Hunt, Aaron Isaacs, Till Ittermann, Ingegerd Johansson, Thorhildur Juliusdottir, Ioanna Panagiota Kalafati, Leena Kinnunen, Wolfgang Köenig, Ishminder K. Kooner, Wolfgang Kratzer, Claudia Lamina, Karin Leander, Sang Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Rebecca Mills, Alireza Moayyeri, Keri L. Monda, Simon P. Mooijaart, Antonella Mulas, Gabriele Müller, Martina Müller‐Nurasyid, Ramaiah Nagaraja, Michael A. Nalls, Narisu Narisu, Nicola Glorioso, Ilja M. Nolte, Matthias Olden, Nigel W. Rayner, Frida Renström, Janina S. Ried, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Bengt Sennblad, Thomas Seufferlein, Colleen M. Sitlani, Albert V. Smith, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann‐Christine Syvänen, Bamidele O. Tayo, Barbara Thorand, Guðmar Þorleifsson, Andreas Tomaschitz, Chiara Troffa, Floor V. A. van Oort, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Roman Wennauer, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Qunyuan Zhang, Wei Zhao, Eoin Brennan, Murim Choi, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, Ali G. Gharavi, Åsa K. Hedman, Marie‐France Hivert, Jinyan Huang, Stavroula Kanoni, Fredrik Karpe, Sarah Keildson, Krzysztof Kiryluk, Liming Liang, Richard P. Lifton, Baoshan Ma, Amy Jayne McKnight, Ruth McPherson, Andres Metspalu, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, Dale R. Nyholt, Christian Olsson, John R. B. Perry, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Eric E. Schadt, Robert A. Scott, Lisette Stolk, Edgar E. Vallejo, Harm-Jan Westra, Krina T. Zondervan, Philippe Amouyel, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Michel Burnier, Harry Campbell, Aravinda Chakravarti, Peter S. Chines, Francis S. Collins, Dana C. Crawford, John Danesh, Ulf dé Fairé, Eco J. C. de Geus, Marcus Dörr, Raimund Erbel, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Christian Gieger, Vilmundur Guðnason, Christopher A. Haiman, Tamara B. Harris, Andrew T. Hattersley, Markku Heliövaara, Andrew A. Hicks, Aroon D. Hingorani, Wolfgang Hoffmann, Albert Hofman, Georg Homuth, Steve E. Humphries, Elina Hyppönen, Thomas Illig, Marjo‐Riitta Järvelin, Berit Johansen, Antti Jula, Jaakko Kaprio, Frank Kee, Sirkka Keinänen‐Kiukaanniemi, Jaspal S. Kooner, Charles Kooperberg, Péter Kovács, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loı̈c Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Arthur W. Musk, Stefan Möhlenkamp, Andrew D. Morris, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Lyle J. Palmer, Brenda W.J.H. Penninx, Annette Peters, Peter P. Pramstaller, Olli Raitakari, Tuomo Rankinen, D. C. Rao, Treva Rice, Paul M. Ridker, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Peter Schwarz, Alan R. Shuldiner, Jan A. Staessen, Valgerður Steinthórsdóttir, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, Angelo Tremblay, Elena Tremoli, Marie‐Claude Vohl, Uwe Völker, Péter Vollenweider, Jacqueline C.M. Witteman, Linda S. Adair, Murielle Bochud, Bernhard O. Boehm, Stefan R. Bornstein, Claude Bouchard, Stéphane Cauchi, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, George Dedoussis, Luigi Ferrucci, Philippe Froguel, Hans J. Grabe, Anders Hamsten, Jennie Hui, Kristian Hveem, Karl‐Heinz Jöckel, Mika Kivimäki, Diana Kuh, Markku Laakso, Winfried März, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Nancy L. Pedersen, Markus Perola, Louis Përusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo Saaristo, Danish Saleheen, Juha Sinisalo, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Þorsteinsdóttir, Michael Stümvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Giovanni Veronesi, Mark Walker, Nicholas J. Wareham, Hugh Watkins, H‐Erich Wichmann, Gonçalo R. Abecasis, Themistocles L. Assimes, Sonja I. Berndt, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Lude Franke, Timothy M. Frayling, David J. Hunter, Robert C. Kaplan, Jeffrey R. O’Connell, Lu Qi, David Schlessinger, David P. Strachan, Kāri Stefánsson, Cornelia M. van Duijn, Cristen J. Willer, Peter M. Visscher, Jian Yang, Joel N. Hirschhorn, M. Carola Zillikens, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Caroline S. Fox, Inês Barroso, Paul W. Franks, Erik Ingelsson, Iris M. Heid, Ruth J. F. Loos, L. Adrienne Cupples, Andrew P. Morris, Cecilia M. Lindgren, Karen L. Mohlke
Bibliographic record
VenueNature · 2015
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsOntario Institute for Cancer ResearchUniversity of TorontoInstitut universitaire de cardiologie et de pneumologie de QuébecUniversité LavalUniversity of Ottawa
FundersNational Institute on Minority Health and Health DisparitiesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on AgingEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentEconomic and Social Research CouncilCancer Research UKNovo Nordisk FondenDiabetes UKNational Institute of General Medical SciencesNational Institute for Health and Care ResearchNational Human Genome Research InstituteWellcome TrustNational Cancer InstituteBritish Heart FoundationNational Institutes of HealthLundbeckfondenMedical Research CouncilNational Heart, Lung, and Blood InstituteUniversity of WarwickNational Institute on Drug AbuseMcKnight Foundation
KeywordsAdipose tissueBiologyLink (geometry)GeneticsInsulinEndocrinologyComputer science
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.008
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.017
GPT teacher head0.331
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations1,710
Published2015
Admission routes1
Has abstractno