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Record W2047950255 · doi:10.1159/000196983

Effect of Sex Hormones on Gastric Secretion and on Gastric Mucosa in Oophorectomized Histamine Stimulated Rats

2009· article· en· W2047950255 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDigestion · 2009
Typearticle
Languageen
FieldMedicine
TopicGastrointestinal motility and disorders
Canadian institutionsAlberta Medical AssociationUniversity of Alberta
Fundersnot available
KeywordsHistamineInternal medicineEndocrinologyGastric mucosaHormonePepsinMedicineStomachEstronePepticTestosterone (patch)CastrationSecretionStimulationAndrogenChemistryPeptic ulcer

Abstract

fetched live from OpenAlex

Gastric secretory function was studied for 24 h in rats bearing permanent gastric fistulas and permanent intravenous cannulas. Rats were oophorectomized and treated for five months with testosterone or estrone, prior to gastric function studies. Gastric juice was collected for 24 h during the infusion of saline or histamine, and then gastric examined for the presence of peptic ulcers. All androgen-treated rats had peptic ulcers at the end of 24 h histamine infusion. Only 14% of estrone-treated rats had these lesions, under similar stimulation. All ulcers were localized in glandular mucosa. No ulcers were found in oophorectomized, untreated controls, infused with histamine. Volume, HCl and pepsin output were not affected by hormonal treatment. Androgen enhanced the susceptibüity of gastric mucosa to the peptic action of gastric juice. However, the study of gastric function did not explain this ulcerogenic effect of male sex hormone.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.517
Threshold uncertainty score0.614

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.256
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it