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Record W2048286711 · doi:10.1159/000241374

Effects of Dexamethasone on Fetal Mouse Development

2009· article· en· W2048286711 on OpenAlexaff
L. Tye, A.F. Burton

Bibliographic record

VenueBiology of the Neonate · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMetabolism and Genetic Disorders
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsDexamethasoneFetusThymidineUridineEndocrinologyInternal medicineMicrogramGestationLungIn vitroCorticosteroidGestational ageBiologyChemistryMedicinePregnancyBiochemistryRNA

Abstract

fetched live from OpenAlex

The in vitro incorporation of 14C-leucine, 3H-uridine and 3H-thymidine into the acid-insoluble components of mouse fetal liver, gut, heart and lung as followed on gestational days 14, 16 and 19. Liver and gut showed a similar pattern: the incoporation of all three substrates decreased steadily until day 19, falling from one tenth to one fifth the values on day 14. Heart and lung decreased by half after day 16. Injection of mothers 16 h earlier with 200 microgram dexamethasone decreased in vitro incorporation on day 14 into liver and gut, respectively, of leucine by 38 and 37% and of thymidine by 67 and 56%. In heart and lung, only thymidine was decreased at this time by 61 and 33%, respectively. Values for uridine were affected significantly only in liver. Thymidine incorporation appeared to be the most sensitive parameter reflecting corticosteroid action and liver the most sensitive tissue. Treated fetuses were born at the usual time and weight gain did not differ from controls over the first 42 days neonatally. It is concluded that dexamethasone accelerates the development of many processes in fetal tissues which are induced by corticosteroids.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.054
Threshold uncertainty score0.266

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.223
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2009
Admission routes1
Has abstractyes

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