Effect of Diabetes in the BB Wistar Rat on the Peptidergic Component of the Enteric Innervation
Bibliographic record
Abstract
Whole mount preparations of the small intestine from Wistar, normoglycemic 90-day diabetic BB, hyperglycemic 90-day diabetic BB and age-matched nondiabetic BB rats were immunostained to determine the extent of the peptidergic innervation. The neuropeptides examined were vasoactive intestinal peptide, neuropeptide Y, substance P. calcitonin gene-related peptide, galanin and somatostatin. The extent of the peptidergic innervation in the submucous and myenteric plexuses from the control Wistar, nondiabetic BB and normoglycemic diabetic BB rats was identical. In the submucous plexus of the hyperglycemic diabetic BB rats there was a marked reduction in the number of somatostatin-immunoreactive neurons and nerve fibres. Substance P and calcitonin gene-related peptide which are colocalized in a proportion of the somatostatin neurons were unaffected. In the myenteric plexus of the hyperglycemic diabetic BB rats the number and intensity of staining of the galanin-immunoreactive nerve fibers was markedly increased. Galanin has not been observed to colocalize with any of the other neuropeptides examined.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".