MétaCan
Menu
Back to cohort
Record W2048674627 · doi:10.1021/om020914p

Mechanistic Studies of the Addition of Carbonyl Compounds to Tetramesityldisilene and Tetramesitylgermasilene

2003· article· en· W2048674627 on OpenAlexaff
M. S. Samuel, Hilary A. Jenkins, Donald W. Hughes, Kim M. Baines

Bibliographic record

VenueOrganometallics · 2003
Typearticle
Languageen
FieldChemistry
TopicSynthesis and characterization of novel inorganic/organometallic compounds
Canadian institutionsMcMaster UniversityWestern University
Fundersnot available
KeywordsChemistryAldehydeSubstituentTrimethylsilylRegioselectivitySilylationMedicinal chemistryRing (chemistry)Reaction mechanismStereochemistryOrganic chemistryCatalysis

Abstract

fetched live from OpenAlex

The mechanism for the addition of carbonyl compounds to disilenes and germasilenes was investigated by examination of the structure of the products obtained from the reaction of the modified mechanistic probe, trans, trans -2-methoxy-3-phenylcyclopropane carbaldehyde, with tetramesityldisilene and tetramesitylgermasilene. The aldehyde was found to undergo characteristic ring-opening reactions depending on whether a radical or a cation develops at the carbinyl carbon. Thus, reaction of the mechanistic probe under ionic conditions ( p -TsOH) yielded a mixture of cis - and trans -2-methoxy-3-phenyl-2,3-dihydrofuran ( 6 ) from ring-opening toward the methoxy substituent. In contrast, reaction of the mechanistic probe under radical conditions (HSi(SiMe 3 ) 3, AIBN) yielded a mixture of cis- and trans- 3-methoxy-4-phenyl-1-[tris(trimethylsilyl)siloxy]but-1-ene ( 7 ) from regioselective ring-opening toward the phenyl substituent. 2,2,3,3-Tetramesityl-4-phenyl-5-methoxyoxa-2,3-disilacyclohept-6-ene ( 8 ) was formed from the reaction between the aldehyde and tetramesityldisilene, and a mixture of three isomers of 2,2,3,3-tetramesityl(phenyl)(methoxy)oxagermasilacyclohept-6-ene ( 10a − c ) and [dimesityl(1-oxa-4-methoxy-5-phenylpentadienyl)silyl]germane ( 10d ) was formed in the reaction of the aldehyde with tetramesitylgermasilene. The formation of 8, 10a, 10b, and 10d provides unequivocal evidence for the presence of radical intermediates in the addition of carbonyl compounds to the disilene and germasilene.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.249
Teacher spread0.223 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2003
Admission routes1
Has abstractyes

Explore more

Same venueOrganometallicsSame topicSynthesis and characterization of novel inorganic/organometallic compoundsFrench-language works237,207