Serum Gonadotropin Patterns in Patients with Chronic Renal Failure on Hemodialysis
Bibliographic record
Abstract
A clinical model to study gonadotropin patterns when minimal or no kidney function persists is available in patients demonstrating chronic renal failure and maintained on hemodialysis. Hemodialysis does not alter the serum level of FSH and LH. In 9 premenopausal women, 3 serum patterns of FSH and LH were observed. The most common serum pattern of gonadotropin is a normal concentration of FSH and a moderately elevated level of LH, wherein LH/FSH is 4:1. This pattern was also observed in 4 male patients maintained on hemodialysis. The serum gonadotropin pattern in oophorectomized women on hemodialysis is the same as in post-menopausal women with normal renal function (i.e. high LH and high FSH). Serum estrogen levels are below normal in all female patients studied. Renal failure does not induce a suppression in the hypothalamic-pituitary control of gonadotropin release. Renal failure is not associated with an unique serum pattern of FSH and LH. This suggests that kidney excretion is not the only mechanism for clearing gonadotropin from blood.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".