Human Neonatal Monocyte-Derived Macrophages and Neutrophils Exhibit Normal Nonopsonic and Opsonic Receptor-Mediated Phagocytosis and Superoxide Anion Production
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Human neonates are at risk for invasive infections with fungi and gram-negative bacteria, microorganisms which are often susceptible to phagocytosis in either the presence or the absence of opsonins. Although opsonic phagocytosis has been investigated, to date there have been no systematic studies of nonopsonic phagocytosis in neonates. We investigated receptor-mediated phagocytosis by neonatal neutrophils and monocyte-derived macrophages in order to determine if a functional defect exists in any of the classes of nonopsonic or opsonic receptors. Ingestion or binding by mannosyl/fucosyl, Fc and complement receptors and the receptor(s) for unopsonized Pseudomonas aeruginosa were normal in neutrophils and macrophages from the cord blood of 26 healthy full-term neonates as compared to simultaneous normal adult controls. Superoxide anion production by neonatal neutrophils in response to both soluble and particulate stimuli was also normal. We conclude that neonatal nonopsonic and opsonic receptor-mediated phagocytosis are normal.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it