Exploratory Drive, Frontal Lobe Function and Adipsia in Aging
Bibliographic record
Abstract
Aging in animals in accompanied by a decrease in exploratory drive, as assessed by hole poking and spontaneous alternation tests. This decrease is caused either by increased fear of the novel testing environment (neophobia) or by apathy. Either cause may be related to dysfunction of prefrontal cortex-related pathways. The myelination of the prefrontal cortex appears late in ontogeny. In accordance to the last-in first-out principle, this brain region seems to be affected early during aging. It remains to be determined whether this decrease of exploratory behavior is reversible by behavioral intervention, by dietary changes or by the administration of psychotropic drugs. One hypothesis worth testing is whether the decrease in exploration is associated to the well-described adipsia in human aging, whose neurobiological basis has not yet been determined. It is possible to consider that the maladaptive response to thirst is responsible for some senescent changes in the brain and that reversal of adipsia by behavioral, dietary or pharmacological means improves the quality of life in the elderly.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".