Neurodevelopmental outcomes in children with Angelman syndrome after 1 year of behavioural intervention
Bibliographic record
Abstract
OBJECTIVE: To examine the impact of teaching approaches based on the principles of applied behaviour analysis (ABA) on neurodevelopmental outcomes in children with Angelman syndrome (AS). METHODS: A non-randomized pre-test-post-test control group design was used. The intervention group consisted of four children with AS aged 3.1-9.2 years. Controls were other children with AS who were individually matched on the basis of chronological age, gender and molecular sub-type. Children in the intervention group were provided two-to-three ABA-based therapy sessions per week over a 1-year period. Standardized measures of cognitive, adaptive and language functioning were administered at baseline and after 1 year. RESULTS: There were no statistically significant differences between the two groups at baseline or after 1 year. However, positive trends were observed in the intervention group for some cognitive and adaptive measures. CONCLUSION: ABA-based intervention improved aspects of neurodevelopment for some children with AS and warrants further study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".