A Role for Epithelial-Mesenchymal Interactions in Tail Growth/Morphogenesis and Chondrogenesis in Embryonic Mice
Bibliographic record
Abstract
Neurulation involves development from primary germ layers before any differentiation of embryonic mesenchyme. Subsequently, secondary organogenesis is via epithelial-mesenchymal interaction. It is unclear whether formation of the caudal body axis and tail bud in vertebrate embryos is by temporal and causal extension of primary neurulation, by secondary neurulation, or by secondary induction (epithelial-mesenchymal interactions) as seen in organogenesis of the limb buds, kidneys, heart and other embryonic regions. Reports of a ventral ectodermal ridge (VER) associated with tail bud development in rodent embryos imply that tail bud development may share features with limb bud development, in which the apical ectodermal ridge (AER) directs limb bud outgrowth and skeletal patterning. Organ culture or grafting to the chorioallantoic membranes of host chick embryos, of tail bud mesenchyme with or without tail epithelium, demonstrates that both survival and growth of tail mesenchyme depend on the presence of tail epithelium. Initiation of chondrogenesis of tail mesenchyme was similarly dependent on tail epithelium until 10.5 days of gestation, which is when the VER is at its maximal extent. Initiation of myogenesis was independent of the presence of tail epithelium. These results are discussed in relation to the similarity of tail bud to limb bud developed, and to the different mechanisms employed in differentiation of the cranial and caudal ends of vertebrate embryos. Secondary induction of the caudal body region is argued to be fundamental in vertebrate embryogenesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".