Antioxidant vitamins inhibit progression of hypertension and improve endothelial dysfunction and antioxidant status in SHRSP
Bibliographic record
Abstract
We investigated effects of vitamins C and E on blood pressure elevation, vascular remodeling and endothelial function in salt-loaded stroke-prone SHR (SHRSP). The role of oxidative stress was also assessed in these processes. 16 week-old SHRSP (n = 16) on a high salt diet (4% NaCl) were randomly divided into 3 groups: control (C), Vit C (1000 mg/d) and Vit E (1000 IU/d). Systolic blood pressure (SBP) and plasma antioxidant status (spectrophotometric assay system) were assessed weekly. 6 weeks after treatment rats were killed. Vascular structure (media:lumen ratio) and endothelial function (ACH-induced vasodilation) were assessed in mesenteric arteries. Vascular •O2− production was measured in aortic vessels using lucigenin (5 μM). SBP increased progressively from 204 ± 9.4 to 246 ± 5.6 mmHg in C group. Progression of hypertension was prevented in Vit C (210 ± 5 mmHg) and Vit E (209 ± 11 mmHg) groups. Ach-induced dilation was significantly improved in the treated groups. Media:lumen ratio was reduced (p < 0.001) in Vit E group (6.8 ± 0.8%) vs C group (12.3 ± 0.1%0. Total antioxidant status was significantly improved (p < 0.05) in the Vit C (1.3 ± 0.2 mM) and Vit E (1.68 ± 0.4 mM) groups compared with C (0.87 ± 0.1 mM). •O2− production was significantly lower in both Vit-treated groups compared with the untreated group. Vits C and E improved endothelial dysfunction in small arteries and prevented the progression of hypertension in salt-loaded SHRSP. Vit E also corrected vascular remodeling. These effects were associated with improved antioxidant status and reduced vascular oxidative stress. Thus beneficial effects of antioxidant vitamins in vascular damage associated with hypertension are related, in part, to alterations in vessel redox state.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".