Simulation of Dendritic Ca<sub>V</sub>1.3 Channels in Cat Lumbar Motoneurons: Spatial Distribution
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Bibliographic record
Abstract
We used computer simulations to study the dendritic spatial distribution of low voltage-activated L-type calcium (Ca(V)1.3 type) channels, which mediate hysteretic persistent inward current (PIC) in spinal motoneurons. This study was prompted by the growing experimental evidence of the functional interactions between synaptic inputs and active conductances over the motoneuron dendritic tree. A compartmental cable model of an adult cat alpha-motoneuron was developed in NEURON simulation environment constituting the detailed morphology of type-identified triceps surae alpha-motoneuron and realistic distribution of group Ia afferent-to-motoneuron contacts. Simulations of different distributions of Ca(V)1.3 channels were conducted and the resultant behavior was compared to experimental data. Our results suggest that Ca(V)1.3 channels do not uniformly cover the whole motoneuron dendritic tree. Instead, their distribution is similar to that of synaptic contacts. We found that Ca(V)1.3 channels are primarily localized to a wide intermediate band overlapping with the dendritic Ia-synaptic territory at dendritic distances of 300 to 850 microm (0.62 +/- 0.21lambda) from the soma in triceps surae alpha-motoneurons. These findings explain the functional interaction between synaptic inputs and the Ca(V)1.3 channels over the motoneuron dendritic tree.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it