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Record W2050673942 · doi:10.1159/000122847

Unsuppressed Prolactin Secretion in the Male Rat is Pulsatile

2008· article· en· W2050673942 on OpenAlexaff
Seon H. Shin, Hao Chi

Bibliographic record

VenueNeuroendocrinology · 2008
Typearticle
Languageen
FieldMedicine
TopicHypothalamic control of reproductive hormones
Canadian institutionsQueen's University
Fundersnot available
KeywordsEndocrinologyInternal medicineProlactinPulsatile flowPimozideDopaminergicHypothalamusAgonistSecretionReceptorChemistryBiologyMedicineHormoneDopamineHaloperidol

Abstract

fetched live from OpenAlex

The pattern of prolactin (Prl) secretion was studied in several different situations. In normal and castrated male rats, the plasma Prl level gently fluctuated along the course of time. When the presumed hypothalamic Prl inhibitory factor was suppressed by treatment with a pharmacological agent, pimozide (Pim), the plasma Prl concentration was elevated and the elevated plasma level fluctuated in an irregular and pulsatile manner. Another situation was examined. First, baseline Prl concentration was elevated by implantation of estradiol, which also caused a moderate fluctuation of the circulating Prl level. The Prl level was then lowered from the elevated plateau level by administration of a dopaminergic receptor agonist, ergocristine. During this partial blockade, the plasma Prl level fluctuated in episodic bursts. It is suggested that the inherent, unsuppressed secretion of Prl is pulsatile in nature, but that this pulsatile pattern is normally suppressed under the inhibiting influence of the hypothalamus.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.280
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.268
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations30
Published2008
Admission routes1
Has abstractyes

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