Essentiality of nickel and homeostatic mechanisms for its regulation in terrestrial organisms
Bibliographic record
Abstract
Nickel (Ni) is a naturally occurring element with many industrial uses, including in stainless steel, electroplating, pigments, and ceramics. Consequently, Ni may enter the environment from anthropogenic sources, resulting in locally elevated concentrations in soils. However, Ni is a minor essential element, and, therefore, biota have established systems that maintain Ni homeostasis. This paper discusses the role of Ni as an essential element and reviews storage, uptake, and transport systems used to maintain homeostasis within terrestrial biota. The bioaccumulation and distribution of metals in these organisms are also addressed. In all cases, information on Ni essentiality is very limited compared to other essential metals. However, the available data indicate that Ni behaves in a similar manner to other metals. Therefore, inferences specific to Ni may be made from an understanding of metal homeostasis in general. Nevertheless, it is evident that tissue and organ Ni concentrations and requirements vary considerably within and between species, and metal accumulation in various tissues within a single organism differs as well. High rates of Ni deposition around smelters indicate that Ni in acidic soils may reach concentrations that are toxic to plants and soil decomposers. However, with the exception of hyperaccumulator plants, Ni does not biomagnify in the terrestrial food web, suggesting that toxicity to higher trophic levels is unlikely.Key words: nickel, essentiality, homeostasis, bioaccumulation, uptake, transport.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".