A fiber-coupled microfluidic cytometer for the obtaining of nanostructural mitochondria information in single cells
Bibliographic record
Abstract
A fiber-coupled microfluidic cytometer has been recently developed in our group for the obtaining of 2D light scatter patterns from single biological cells. The obtained scatter patterns may be used for label-free characterization of biological cells. Understanding of these 2D scatter patterns can be better achieved by comparing the experimental results with those obtained by theoretical simulations, such as the finite-difference time-domain (FDTD) simulation of light scattering from biological cells. In this paper, we provide detailed study for applying the FDTD method in our fibercoupled microfluidic cytometer. The FDTD simulation results agree reasonably well with the experimentally obtained THP-1 cell 2D scatter patterns. Methods for scatter pattern analysis are under development in our group for new light scattering parameters that may potentially be used in clinics.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".