Disruption of the endocannabinoid system is prominent in lung adenocarcinoma and associated with poor patient survival
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Background The endocannabinoid system (ECS) is comprised of cannabinoid receptors, lipid messengers called endocannabinoids, and the enzymes that metabolize them. It modulates numerous processes including the central nervous and immune systems as well as cell signaling pathways important in normal function and diseases such as cancer. Many studies have demonstrated anti-tumour effects of synthetic and endogenous cannabinoids in cancer, emphasizing the potential for ECS modulators as anti-cancer therapies. We believe that ECS deregulation may contribute to the malignant phenotype of lung cancer cells by reducing anti-tumour endocannabinoid levels and consequently increasing levels of arachidonic acid, which can promote tumour growth. We sought to determine whether the ECS is disrupted in clinical lung tumours and whether disruption has prognostic implications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it