The importance of yeast Alr proteins in cadmium detoxification as indicated by particle‐induced x‐ray emission and phenotypic analyses
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract One gene in Saccharomyces cerevisiae, ALR1 , encodes a transmembrane protein involved in the transport of Mg 2+ into cells. Overexpression of this gene changes the tolerance of S. cerevisiae to several metal cations. In order to study the cellular uptake mechanism of metal cations in S. cerevisiae , an accurate determination of the metals present in the cells is needed. In this work, particle‐induced x‐ray emission (PIXE) was employed to analyze the intracellular metal content after cell exposure to cadmium. To that end, a specific method for sample preparation was developed. The samples were irradiated with a 2 MeV proton beam, while the induced x‐rays were detected with a high‐purity germanium detector. The PIXE results for cadmium‐exposed ALR1 mutant and wild‐type yeast cells suggest that Alr1p has a central role in the cell survival process in a cadmium‐rich environment. Copyright © 2005 John Wiley & Sons, Ltd.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it