International Consensus Conference on Atopic Dermatitis II (ICCAD II*): clinical update and current treatment strategies
Bibliographic record
Abstract
* The first ICCAD meeting was held in Rome in 1999, the proceedings of which were published in the Journal of the American Academy of Dermatology (2001;45: S1−67). Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease, characterized by intense itching, dry skin, inflammation and exudation. It causes physical and emotional distress for patients and their families. The first symptoms commonly develop in infancy, with around 50% of cases diagnosed by 1 year of age,1 and AD is typically a long‐term condition with at least one‐third of patients having persistent disease throughout adulthood. However the vast majority of cases of atopic dermatitis are mild in severity and usually can be managed easily.2 The disease is often familial and frequently associated with asthma, food allergy, allergic rhinitis and recurrent secondary skin infections. Atopic dermatitis has significant impact on quality of life in both children3 and adults.4 The impact is greater than with psoriasis and is equivalent to other serious medical conditions such as early onset of diabetes mellitus.5 The prevalence of atopic dermatitis has increased steadily in recent decades.4 In developed countries approximately 10–15% of children under 5 years of age are affected at some stage.4 The likelihood is that 60% of children with atopic dermatitis may recover free of the disease, the remainder having recurrences for long periods of time.6 It has also been suggested that the best prognosis for the disease is in those children who developed AD in the first year of life.7 However, overall the earlier the onset and the more severe the disease, there is a greater chance of persistence, especially with concurrent atopic disorders. Recent evidence has indicated a common pathophysiological link between severe atopic dermatitis, asthma and allergic rhinitis8, 9 (for example both asthma and AD are associated with increased IgE and eosinophilia). It has been suggested that atopic dermatitis may increase the subsequent risk or severity of asthma.10
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.011 | 0.013 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.004 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".