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Record W2054000192 · doi:10.1016/s0002-9440(10)64902-4

Considerations When Analyzing the Methylation Status of PTEN Tumor Suppressor Gene

2002· article· en· W2054000192 on OpenAlexafffund
Michele Zysman, William Chapman, Bharati Bapat

Bibliographic record

VenueAmerican Journal Of Pathology · 2002
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPI3K/AKT/mTOR signaling in cancer
Canadian institutionsUniversity Health NetworkUniversity of TorontoMount Sinai HospitalToronto Public HealthLunenfeld-Tanenbaum Research Institute
FundersUniversity of TorontoConcern Foundation
KeywordsPTENSuppressorTumor suppressor geneMethylationDNA methylationBiologyGeneCancer researchEpigeneticsGeneticsBioinformaticsComputational biologyCarcinogenesisGene expressionSignal transductionPI3K/AKT/mTOR pathway

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.061
metaresearch head score (Gemma)0.069
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.061
Threshold uncertainty score0.321

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0610.069
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0070.003
Science and technology studies0.0030.005
Scholarly communication0.0050.003
Open science0.0030.002
Research integrity0.0040.005
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.274
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations111
Published2002
Admission routes2
Has abstractno

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