H <sub>2</sub> S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
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Abstract
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.
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The record
- Venue
- Science
- Topic
- Sulfur Compounds in Biology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Lakehead UniversityUniversity of Saskatchewan
- Funders
- National Institute on Drug AbuseNational Institute of Mental Health
- Keywords
- Cystathionine beta synthaseCystathionine gamma-lyaseNitric oxideHydrogen sulfideVasodilationChemistryMutantCalciumPharmacologyBlood pressureEnzymeBiochemistryMedicineInternal medicineGeneCysteine
- Has abstract in OpenAlex
- yes