Cysteamine Acts Immediately to Inhibit Prolactin Release and Induce Cellular Changes in Estradiol-Primed Male Rats
Bibliographic record
Abstract
Cysteamine (CSH) has an inhibitory effect on the secretion of PRL, GH and TSH. The purpose of the present study was twofold: (1) to examine the short-term effects of CSH on PRL secretion, and (2) to elucidate the mechanism of action of CSH. CSH (100 mg/kg) was injected as an intra-atrial bolus to both normal and estradiol-primed male Sprague-Dawley rats. Blood samples were drawn every 2 min for 1 h and assayed for PRL. To determine if the actions of CSH involved PIF release or PIF receptors, a dopamine receptor blocking agent, pimozide (100 micrograms/kg) was given intra-atrially 1 h after the CSH injection and PRL concentration was monitored. Within 6 min after the CSH injection PRL levels in estradiol-primed rats began to fall, and by 30 min postinjection the levels were well below baseline values. Blocking the dopamine receptors with pimozide did not result in increased PRL levels, indicating that CSH was acting through some mechanism not directly involving dopaminergic PIF receptors. In a separate study, 6 min after the injection of CSH the rats were decapitated and their anterior pituitaries were removed and processed for electron microscopy. Only mammotrophs from estradiol-primed rats treated with CSH showed an extensive rearrangement of rough endoplasmic reticulum (RER) in concentric whorls around the periphery of the cells. These studies show that the inhibition of PRL secretion by CSH begins within 6 min, and is appreciable only when basal PRL levels are increased by estrogen priming.(ABSTRACT TRUNCATED AT 250 WORDS)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".